Cleaning and Cleaning Validation

Is it permissible to use the same equipment to manufacture different products for different therapeutic groups?

What would be the clean down arrangements/requirements when switching between different product types?

R&D want to share manufacturing equipment used for fully marketed product, as QP what are your concerns.

What are the carry-over limits for impurities in products.

Tell me about cleaning validation for a multi product facility when full toxicity/potency etc. data is not available.

How would you apply your knowledge of therapeutics to manufacture?  

What factors are important for a multi-product facility?

How do you set limits for cleaning validation?

What do you need to consider when setting limits? What might be a limiting factor?

How would you validate a cleaning procedure? What's important from the analytical point of view?

What is a common acceptance level for carry-over in cleaning validation?

What is an easy method you could use for detection? What are its advantages and weaknesses?

You mentioned the drug, what about detergents?